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[Solved] BIF401 GDB Spring 2020  

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21/07/2020 1:28 am  

BIF401 Bioinformatics I GDB Solution & Discussion Spring 2020


How Bioinformatics help in drug discovery for COV-19?

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admin
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21/07/2020 1:29 am  

BIF401 Bioinformatics I GDB Solution & Discussion Spring 2020


BIF401 GDB solution idea:

 

In this challenging scenario, Bioinformatics came out as one of the essential tools to analyze viral data as it provides vital information about the genetic makeup of the virus and also assists directly in the development of drugs or vaccines against the deadly disease.

Instead of doing a bunch of experiments without a clear goal, a few can be tested as predicted by Bioinformatics by analyzing the available data.

In the current COVID-19 crisis also Bioinformatics is playing a crucial role by predicting suitable drugs against viral targets and subsequently these are now being tested in the laboratory for validation.

To develop a potent drug against COVID-19 Bioinformatics can help by predicting possible molecules as inhibitors for the virus that can be tested in the laboratory for efficacy.

From analyzing the sequence to the final drug candidate prediction requires several steps to follow which can be broadly divided into five segments – retrieval of the viral sequence from the nucleic acid database, analysis of the sequence data by comparison with other viral sequences, phylogenetic analysis of the viral sequences to find out how the target virus evolved from others, computational modeling of the important viral proteins as drug targets, and finally test several drug molecules against the viral proteins for inhibitory activities.

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admin
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Admin
Joined: 2 years ago
Posts: 3586
21/07/2020 1:29 am  

BIF401 Bioinformatics I GDB Solution & Discussion Spring 2020


BIF401 GDB solution idea:

 

Bioinformatics provides us wide range of online database and tool, which helps us in drugs designing and development in the drug discovery. Bioinformatics has a great role in molecular data, helps to predict the structure of protein. This structure of protein helps the pharmacologist to build up the vaccine against the viral disease. One of the most important role in field of pharmacology, which identify drug targets that can either restore cellular function or eliminate malfunctioning cells. Bioinformatics helps us the build the structure of RNA, which suppress the expression the viral gene. It has great role in RNAi technology, which is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules. Historically, RNAi was known by other names, including co-suppression, posttranscriptional gene silencing (PTGS), and quelling. In this current situation of COVID-19 crisis, Bioinformatics is playing a crucial role by predicting suitable drugs against viral targets and subsequently these are now being tested in the laboratory for validation. A potent drug against COVID-19 Bioinformatics can help by predicting possible molecules as inhibitors for the virus that can be tested in the laboratory. Bioinformatics used the computational modeling of the important viral proteins as drug targets, and finally test several drug molecules against the viral proteins for inhibitory activities. Bioinformatics helps us to build the essential proteins of the virus; the virus can be stopped from further infecting others. The final step in the process is to form the antiviral protein and modify the structures of existing drug molecules against the viral proteins to see whether these molecules are binding to the important sites on the viral proteins by computational analysis.

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